Glial cell migration

Across TCGA cell cohorts, RNA activity of the Glial cell migration pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NOCT, TVP23A, and NOTCH2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NOCT grouped by Glial cell migration-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	NOCT →	+0.730	+0.949	.008	.008	3	4
CNS	TVP23A →	-0.158	-0.679	.005	.005	3	4
KIDNEY	NOTCH2 →	+1.153	+1.399	.001	<.001	3	3
SOFT_TISSUE	UFSP2 →	+0.651	+0.306	.001	.001	3	3
SOFT_TISSUE	KIF11 →	+0.593	+0.244	.001	.001	3	3
CNS	NAPA →	-0.625	-1.074	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NOCT by Glial cell migration activity — KIDNEY

Explore this box plot interactively →