Adult locomotory behavior

Across TCGA patient cohorts, RNA activity of the Adult locomotory behavior pathway is significantly associated with the RNA expression of multiple genes, with the UVM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BRAF, HECTD4, and HERC1, each associated with the pathway in up to 29 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Adult locomotory behavior activity versus BRAF in UVM (Pearson r = 0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UVM	BRAF →	+0.912	+0.030	<.001	<.001	3	29
DLBC	HECTD4 →	+1.430	+0.039	<.001	<.001	3	27
DLBC	HERC1 →	+0.917	+0.037	<.001	<.001	3	27
THYM	PARGP1 →	+0.867	+0.032	<.001	<.001	3	27
UVM	TTBK2 →	+0.843	+0.030	<.001	<.001	3	26
THYM	PLEKHM3 →	+0.860	+0.032	<.001	<.001	3	26

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008344 vs BRAF — UVM

Explore this scatter interactively →