Adult locomotory behavior

Across TCGA patient cohorts, RNA activity of the Adult locomotory behavior pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SNCG, ZNF728, and EFHD1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Adult locomotory behavior activity versus SNCG in GBM (Pearson r = 0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SNCG →	+1.179	+0.840	.002	.001	3	4
UCEC	ZNF728 →	+0.530	+0.452	.002	.005	3	4
GBM	EFHD1 →	+1.227	+0.853	.002	.002	3	3
COAD	THBS4 →	+1.009	+0.306	<.001	.001	3	3
COAD	EFEMP1 →	+0.992	+0.301	<.001	.009	3	3
UCEC	FAM110D →	+0.408	+0.356	.003	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008344 vs SNCG — GBM

Explore this scatter interactively →