Adult locomotory behavior

Across TCGA cell cohorts, RNA activity of the Adult locomotory behavior pathway is significantly associated with the shRNA dependency of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CLN5, TBCE, and LGALS13, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CLN5 grouped by Adult locomotory behavior-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	CLN5 →	+0.193	+0.168	.001	.004	3	4
PANCREAS	TBCE →	-0.505	-0.221	.005	.003	3	4
LUNG_SCLC	LGALS13 →	+0.281	+0.187	.008	.002	2	5
KIDNEY	SNX13 →	-0.266	-0.271	<.001	<.001	3	4
BLOOD_Leukemia	ATG4B →	+0.164	+0.258	<.001	<.001	3	3
BLOOD_Leukemia	TRIM15 →	+0.360	+0.307	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CLN5 by Adult locomotory behavior activity — OESOPHAGUS

Explore this box plot interactively →