Adult locomotory behavior

Across TCGA cell cohorts, RNA activity of the Adult locomotory behavior pathway is significantly associated with the shRNA dependency of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ALKBH2, VCX2, and TMCO5A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ALKBH2 grouped by Adult locomotory behavior-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	ALKBH2 →	+0.274	+0.239	.003	.003	3	4
PANCREAS	VCX2 →	+0.252	+0.195	<.001	<.001	3	4
KIDNEY	TMCO5A →	+0.325	+0.182	.008	.006	3	4
OVARY	BDP1 →	+0.252	+0.135	<.001	.001	3	4
OVARY	C5AR1 →	-0.139	-0.141	.004	.005	3	4
PANCREAS	LHX5 →	+0.251	+0.150	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ALKBH2 by Adult locomotory behavior activity — BONE

Explore this box plot interactively →