Adult locomotory behavior

Across TCGA cell cohorts, RNA activity of the Adult locomotory behavior pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ENTPD5, POLR3C, and AGAP9, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ENTPD5 grouped by Adult locomotory behavior-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	ENTPD5 →	-0.113	-1.515	.001	<.001	3	3
SOFT_TISSUE	POLR3C →	+0.377	+0.316	.009	.008	3	3
PANCREAS	AGAP9 →	+0.227	+0.980	.001	.006	3	3
OESOPHAGUS	ELOA2 →	-0.146	-0.279	.005	<.001	3	3
UPPER_AERODIGESTIVE_TRACT	SAT2 →	-0.070	-0.197	.001	.009	3	3
BLOOD_Leukemia	GMCL1 →	-0.132	-0.236	.002	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ENTPD5 by Adult locomotory behavior activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →