Adult feeding behavior

Across TCGA patient cohorts, RNA activity of the Adult feeding behavior pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TERF2, TRMT10C, and GALNT2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Adult feeding behavior activity versus TERF2 in PDAC (Pearson r = 0.11).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	TERF2 →	+0.207	+0.077	.002	<.001	3	4
GBM	TRMT10C →	+0.211	+0.062	<.001	.003	3	4
LSCC	GALNT2 →	-0.378	-0.056	.002	.006	3	3
PDAC	RMDN1 →	+0.214	+0.045	.004	.004	3	3
PDAC	ATP5F1D →	+0.491	+0.055	<.001	.002	2	4
PDAC	BOD1L1_S266 →	-0.257	-0.039	.007	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008343 vs TERF2 — PDAC

Explore this scatter interactively →