Adult feeding behavior

Across TCGA cell cohorts, RNA activity of the Adult feeding behavior pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GBE1, CXCL16, and ELF3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GBE1 grouped by Adult feeding behavior-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	GBE1 →	-1.739	-2.055	.003	<.001	2	5
LIVER	CXCL16 →	+2.460	+1.568	<.001	<.001	3	4
BREAST	ELF3 →	+2.544	+0.848	.002	.002	3	4
UPPER_AERODIGESTIVE_TRACT	ANXA5 →	-1.725	-1.194	<.001	<.001	3	4
BREAST	TMEM184A →	+1.370	+0.687	.002	.001	3	4
OVARY	LMNTD2 →	+0.808	+0.806	.001	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GBE1 by Adult feeding behavior activity — BLOOD_Myeloma

Explore this box plot interactively →