Adult feeding behavior

Across TCGA cell cohorts, RNA activity of the Adult feeding behavior pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARSB, SIRPD, and LIMK1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ARSB grouped by Adult feeding behavior-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	ARSB →	+0.238	+1.126	<.001	.002	3	4
BLOOD_Leukemia	SIRPD →	+0.205	+1.182	.002	.001	3	4
BONE	LIMK1 →	+0.173	+1.982	.001	<.001	3	3
BONE	RAB22A →	-0.144	-1.885	<.001	.001	3	3
BLOOD_Leukemia	HNRNPA1L2 →	+0.239	+1.824	.004	<.001	3	3
BLOOD_Leukemia	SVIL-AS1 →	-0.552	-2.539	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ARSB by Adult feeding behavior activity — LUNG_SCLC

Explore this box plot interactively →