Determination of adult lifespan

Across TCGA patient cohorts, RNA activity of the Determination of adult lifespan pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HTATSF1_S498, RPL5, and COG1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Determination of adult lifespan activity versus HTATSF1_S498 in HNSC (Pearson r = 0.28).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	HTATSF1_S498 →	+0.601	+0.050	<.001	.001	3	5
OV	RPL5 →	-0.145	-0.029	<.001	.001	3	4
OV	COG1 →	-0.281	-0.037	<.001	.003	3	4
OV	CRACDL_S490 →	-0.948	-0.041	.001	<.001	3	4
OV	OCIAD1_S122 →	+0.867	+0.075	<.001	<.001	3	4
UCEC	SMC1A →	+0.214	+0.055	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008340 vs HTATSF1_S498 — HNSC

Explore this scatter interactively →