Determination of adult lifespan

Across TCGA patient cohorts, RNA activity of the Determination of adult lifespan pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPM1A, CDCA3, and AK7, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Determination of adult lifespan activity versus PPM1A in BRCA (Pearson r = -0.37).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PPM1A →	-0.439	-0.608	<.001	<.001	3	4
BRCA	CDCA3 →	+0.912	+0.647	.001	.009	3	4
BRCA	AK7 →	-0.495	-0.605	<.001	<.001	3	4
BRCA	JMJD1C →	-0.715	-0.715	<.001	.001	3	4
BRCA	JKAMP →	-0.440	-0.577	<.001	<.001	3	4
GBM	LINC01289 →	+0.195	+0.943	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008340 vs PPM1A — BRCA

Explore this scatter interactively →