Determination of adult lifespan

Across TCGA cell cohorts, RNA activity of the Determination of adult lifespan pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MSH6, KCNMB4, and CCPG1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Determination of adult lifespan activity versus MSH6 in BLOOD_Lymphoma (Pearson r = 0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	MSH6 →	+1.746	+1.223	<.001	.001	2	6
SOFT_TISSUE	KCNMB4 →	+2.969	+1.673	<.001	.001	3	5
SOFT_TISSUE	CCPG1 →	-2.132	-1.580	.006	.002	3	5
BONE	CD55 →	-5.380	-1.575	.004	<.001	3	5
BLOOD_Leukemia	SLC20A2 →	-0.641	-0.825	.003	.008	2	5
PANCREAS	LACC1 →	-1.266	-1.429	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008340 vs MSH6 — BLOOD_Lymphoma

Explore this scatter interactively →