Histone mRNA metabolic process

Across TCGA cell cohorts, RNA activity of the Histone mRNA metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DBN1, BCL3, and PPARGC1B, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Histone mRNA metabolic process activity versus DBN1 in BREAST (Pearson r = 0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	DBN1 →	+1.133	+0.206	.008	.003	3	6
BREAST	BCL3 →	-0.799	-0.168	.008	.001	3	6
KIDNEY	PPARGC1B →	+0.820	+0.218	<.001	<.001	3	6
PANCREAS	SNRPF →	+0.778	+0.230	<.001	.002	3	5
PANCREAS	SAFB →	+0.593	+0.218	.001	.003	3	5
PANCREAS	LSM12 →	+0.702	+0.274	.003	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008334 vs DBN1 — BREAST

Explore this scatter interactively →