Endosome to lysosome transport

Across TCGA patient cohorts, RNA activity of the Endosome to lysosome transport pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KIF18A, CEP78, and NUP85, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endosome to lysosome transport activity versus KIF18A in UCEC (Pearson r = -0.38).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	KIF18A →	-0.683	-0.115	<.001	<.001	3	5
GBM	CEP78 →	-0.580	-0.178	<.001	<.001	3	5
BRCA	NUP85 →	-0.574	-0.179	<.001	<.001	3	4
BRCA	FAM27E3 →	-0.476	-0.177	.003	<.001	3	4
BRCA	BCS1L →	-0.280	-0.151	.007	.001	3	4
CCRCC	PATZ1 →	-0.354	-0.164	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008333 vs KIF18A — UCEC

Explore this scatter interactively →