Endosome to lysosome transport

Across TCGA cell cohorts, RNA activity of the Endosome to lysosome transport pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HCN3, NAXE, and CISH, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endosome to lysosome transport activity versus HCN3 in LUNG_SCLC (Pearson r = 0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	HCN3 →	+1.525	+0.244	.002	.002	3	5
BONE	NAXE →	+0.895	+0.214	.002	.003	3	4
LARGE_INTESTINE	CISH →	+0.651	+0.201	.008	<.001	3	4
BLOOD_Lymphoma	LEPR →	-1.055	-0.174	.005	<.001	3	3
BLOOD_Lymphoma	TMEM214 →	-0.656	-0.202	.005	.003	3	3
BLOOD_Lymphoma	TST →	-2.314	-0.241	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008333 vs HCN3 — LUNG_SCLC

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