Associative learning

Across TCGA patient cohorts, RNA activity of the Associative learning pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are COIL, COIL_T303, and GIT2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Associative learning activity versus COIL in OV (Pearson r = -0.33).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	COIL →	-0.312	-0.037	.002	<.001	3	5
OV	COIL_T303 →	-1.036	-0.027	<.001	.009	3	5
CCRCC	GIT2 →	-0.141	-0.027	<.001	<.001	3	5
GBM	NPEPPS →	+0.263	+0.039	<.001	.003	3	5
LSCC	ECHDC1 →	-0.301	-0.029	.002	.001	3	4
OV	KTN1_S1313 →	+0.611	+0.026	.007	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008306 vs COIL — OV

Explore this scatter interactively →