Associative learning

Across TCGA patient cohorts, RNA activity of the Associative learning pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAP1A, SCARF2, and AEBP1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Associative learning activity versus MAP1A in LSCC (Pearson r = 0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MAP1A →	+1.333	+0.793	<.001	<.001	3	7
OV	SCARF2 →	+0.722	+0.210	.001	.001	3	6
HNSC	AEBP1 →	+0.804	+0.300	.001	.005	3	6
HNSC	TGFB3 →	+0.705	+0.294	<.001	.004	3	6
HNSC	CACNA1C →	+0.514	+0.295	.001	<.001	3	6
LSCC	CALHM5 →	+0.561	+0.425	<.001	.003	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008306 vs MAP1A — LSCC

Explore this scatter interactively →