Regulation of G protein-coupled receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Regulation of G protein-coupled receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LAML cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MEF2C, TEK, and TMOD2, each associated with the pathway in up to 28 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of G protein-coupled receptor signaling pathway activity versus MEF2C in LAML (Pearson r = 0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LAML	MEF2C →	+1.522	+0.045	<.001	<.001	3	27
CHOL	TEK →	+1.539	+0.026	.002	<.001	3	26
CHOL	TMOD2 →	+1.479	+0.027	.003	.003	1	28
KICH	SYNE1 →	+1.155	+0.018	<.001	.001	3	26
LGG	KCNAB1 →	+0.907	+0.016	<.001	<.001	3	26
MESO	S1PR1 →	+1.128	+0.014	<.001	<.001	3	26

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008277 vs MEF2C — LAML

Explore this scatter interactively →