Regulation of G protein-coupled receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Regulation of G protein-coupled receptor signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NUP107, JCAD, and NES, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of G protein-coupled receptor signaling pathway activity versus NUP107 in OV (Pearson r = -0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	NUP107 →	-0.211	-0.017	<.001	.001	3	8
CCRCC	JCAD →	+0.330	+0.032	<.001	<.001	3	8
HNSC	NES →	+0.994	+0.038	<.001	<.001	3	8
CCRCC	LMOD1 →	+0.731	+0.028	<.001	.002	3	8
HNSC	SORBS1 →	+0.542	+0.033	.003	.004	2	8
GBM	TAF2 →	-0.259	-0.050	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008277 vs NUP107 — OV

Explore this scatter interactively →