Regulation of G protein-coupled receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Regulation of G protein-coupled receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SAMD3, KCNA5, and RTN1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of G protein-coupled receptor signaling pathway activity versus SAMD3 in LSCC (Pearson r = 0.13).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SAMD3 →	+0.491	+0.172	<.001	<.001	3	5
PDAC	KCNA5 →	+0.547	+0.244	<.001	<.001	3	4
HNSC	RTN1 →	+0.708	+0.205	.002	<.001	3	4
PDAC	GPBAR1 →	+0.866	+0.233	<.001	.001	3	4
HNSC	CREBRF →	+0.534	+0.201	.001	<.001	3	4
LSCC	FAM83D →	-1.138	-0.186	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008277 vs SAMD3 — LSCC

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