Regulation of G protein-coupled receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Regulation of G protein-coupled receptor signaling pathway pathway is significantly associated with the shRNA dependency of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MFSD11, OR7D4, and ACVR2A, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MFSD11 grouped by Regulation of G protein-coupled receptor signaling pathway-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	MFSD11 →	-0.187	-1.035	.005	.005	3	6
OVARY	OR7D4 →	-0.295	-1.088	.001	.006	3	5
BREAST	ACVR2A →	-0.174	-0.595	<.001	.003	3	5
BONE	GRK2 →	-0.179	-1.679	<.001	<.001	3	5
BLOOD_Myeloma	MAP3K12 →	-0.106	-1.172	<.001	<.001	3	4
BLOOD_Leukemia	EIF2B4 →	+0.214	+1.135	.005	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MFSD11 by Regulation of G protein-coupled receptor signaling pathway activity — SKIN

Explore this box plot interactively →