Regulation of G protein-coupled receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Regulation of G protein-coupled receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EDC3, AGBL5, and KMT5A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, EDC3 grouped by Regulation of G protein-coupled receptor signaling pathway-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	EDC3 →	+0.544	+0.735	.006	.001	3	4
BLOOD_Leukemia	AGBL5 →	+0.830	+0.721	.001	.001	3	4
BONE	KMT5A →	+0.668	+1.315	<.001	.002	3	4
KIDNEY	PTBP1 →	+0.681	+0.977	.003	.002	3	3
KIDNEY	RACGAP1 →	+1.081	+1.754	.006	<.001	3	3
KIDNEY	LBH →	+2.976	+1.277	.005	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

EDC3 by Regulation of G protein-coupled receptor signaling pathway activity — BLOOD_Leukemia

Explore this box plot interactively →