Regulation of G protein-coupled receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Regulation of G protein-coupled receptor signaling pathway pathway is significantly associated with the shRNA dependency of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SDF2, RUVBL2, and RAD54B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SDF2 grouped by Regulation of G protein-coupled receptor signaling pathway-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	SDF2 →	-0.310	-0.265	<.001	<.001	3	4
LIVER	RUVBL2 →	-0.499	-0.265	.001	<.001	3	3
LIVER	RAD54B →	-0.244	-0.265	<.001	<.001	3	3
LIVER	ELP3 →	-0.378	-0.265	<.001	<.001	3	3
BLOOD_Leukemia	PCK2 →	-0.171	-0.208	.002	.007	3	3
BLOOD_Leukemia	SYCP2L →	-0.236	-0.197	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SDF2 by Regulation of G protein-coupled receptor signaling pathway activity — LIVER

Explore this box plot interactively →