Opsonization

Across TCGA patient cohorts, RNA activity of the Opsonization pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RBM25, PARP4_S1722, and RNPS1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Opsonization activity versus RBM25 in LSCC (Pearson r = -0.13).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RBM25 →	-0.234	-0.094	<.001	<.001	3	6
LSCC	PARP4_S1722 →	+0.885	+0.111	<.001	<.001	3	6
COAD	RNPS1 →	-0.187	-0.036	<.001	<.001	3	5
LSCC	SNRNP70 →	-0.247	-0.118	<.001	<.001	3	5
GBM	NNMT →	+0.909	+0.099	.002	.001	3	5
LSCC	RBM14 →	-0.143	-0.095	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008228 vs RBM25 — LSCC

Explore this scatter interactively →