Regulation of blood pressure

Across TCGA cell cohorts, RNA activity of the Regulation of blood pressure pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPIC, CBX7, and TFEB, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of blood pressure activity versus PPIC in CNS (Pearson r = 0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	PPIC →	+1.517	+0.178	<.001	.001	3	4
OVARY	CBX7 →	+0.844	+0.226	<.001	<.001	3	4
OVARY	TFEB →	+1.636	+0.355	<.001	<.001	3	4
KIDNEY	PTPRE →	+1.096	+0.285	.009	.005	2	5
OVARY	THBS1 →	+2.195	+0.252	.002	.001	3	4
OVARY	MTCP1 →	+1.080	+0.251	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008217 vs PPIC — CNS

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