Spermidine metabolic process

Across TCGA patient cohorts, RNA activity of the Spermidine metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DVL2, ROCK2, and USP39, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Spermidine metabolic process activity versus DVL2 in OV (Pearson r = 0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	DVL2 →	+0.392	+0.150	.008	.003	3	4
LUAD	ROCK2 →	+0.277	+0.133	.001	.007	3	3
LUAD	USP39 →	+0.233	+0.170	.001	<.001	3	3
LUAD	NANP →	+0.366	+0.241	<.001	<.001	3	3
LUAD	GAPDHP72 →	+0.125	+0.162	.003	.006	3	3
BRCA	GPR89A →	+0.299	+0.178	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008216 vs DVL2 — OV

Explore this scatter interactively →