Spermine metabolic process

Across TCGA patient cohorts, RNA activity of the Spermine metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PSMB5, YWHAE, and HLA-DRB1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Spermine metabolic process activity versus PSMB5 in LSCC (Pearson r = 0.38).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PSMB5 →	+0.526	+0.129	<.001	<.001	3	6
OV	YWHAE →	+0.325	+0.047	.001	.001	3	6
LSCC	HLA-DRB1 →	-0.380	-0.075	.001	.005	3	6
CCRCC	CD74 →	-0.473	-0.058	.002	.002	2	7
PDAC	ICAM3 →	-0.431	-0.051	.005	.006	2	6
LSCC	PTPRC →	-0.486	-0.068	.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008215 vs PSMB5 — LSCC

Explore this scatter interactively →