Spermine metabolic process

Across TCGA patient cohorts, RNA activity of the Spermine metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRKAG2-AS1, PPA1, and GEN1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Spermine metabolic process activity versus PRKAG2-AS1 in BRCA (Pearson r = 0.17).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PRKAG2-AS1 →	+0.971	+0.222	<.001	.009	3	3
GBM	PPA1 →	-0.403	-0.131	.003	.006	3	3
UCEC	GEN1 →	-0.458	-0.084	.003	.001	3	3
UCEC	RN7SL674P →	+0.818	+0.068	.006	.005	3	3
CCRCC	NUP93 →	-0.285	-0.069	<.001	.009	3	3
CCRCC	EDA2R →	+1.067	+0.125	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008215 vs PRKAG2-AS1 — BRCA

Explore this scatter interactively →