Spermine metabolic process

Across TCGA cell cohorts, RNA activity of the Spermine metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CEP89, CCDC68, and YJU2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CEP89 grouped by Spermine metabolic process-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	CEP89 →	-0.889	-1.186	.003	.004	3	4
PANCREAS	CCDC68 →	+1.887	+1.322	<.001	<.001	3	4
SOFT_TISSUE	YJU2 →	-0.590	-1.107	<.001	.009	3	3
LUNG_SCLC	UCK1 →	-0.890	-0.808	.003	.005	3	3
SOFT_TISSUE	NNMT →	-5.819	-1.297	<.001	.002	3	3
SOFT_TISSUE	TRAPPC5 →	-0.608	-0.978	.002	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CEP89 by Spermine metabolic process activity — PANCREAS

Explore this box plot interactively →