Mineralocorticoid metabolic process

Across TCGA patient cohorts, RNA activity of the Mineralocorticoid metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RSU1, SEPTIN4, and SORBS3, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mineralocorticoid metabolic process activity versus RSU1 in LSCC (Pearson r = 0.37).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RSU1 →	+0.278	+0.085	.002	<.001	3	8
PDAC	SEPTIN4 →	+0.489	+0.043	<.001	<.001	3	7
CCRCC	SORBS3 →	+0.359	+0.055	<.001	<.001	3	7
OV	SYNPO →	+0.376	+0.049	<.001	.002	3	7
LSCC	TNS2_S102 →	+0.649	+0.066	<.001	<.001	3	7
OV	BGN →	+0.909	+0.070	.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008212 vs RSU1 — LSCC

Explore this scatter interactively →