Estrogen metabolic process

Across TCGA patient cohorts, RNA activity of the Estrogen metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are STK17B, MAST3_S782, and PLEKHO2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Estrogen metabolic process activity versus STK17B in LSCC (Pearson r = -0.54).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	STK17B →	-0.307	-0.077	<.001	<.001	3	5
LSCC	MAST3_S782 →	-0.641	-0.065	<.001	<.001	3	5
LSCC	PLEKHO2 →	-0.221	-0.063	<.001	<.001	3	5
LSCC	VSIR →	-0.352	-0.058	<.001	<.001	3	4
LSCC	ETFA →	+0.371	+0.055	<.001	.001	3	4
COAD	SLC27A2 →	+0.470	+0.043	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008210 vs STK17B — LSCC

Explore this scatter interactively →