Estrogen metabolic process

Across TCGA patient cohorts, RNA activity of the Estrogen metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PIGW, FGFR2, and RPS3AP46, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Estrogen metabolic process activity versus PIGW in GBM (Pearson r = -0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PIGW →	-0.378	-0.142	<.001	.007	3	4
HNSC	FGFR2 →	+0.622	+0.116	.003	.001	3	4
COAD	RPS3AP46 →	+0.685	+0.234	.003	<.001	3	3
HNSC	SYNPR-AS1 →	+0.715	+0.198	<.001	<.001	3	3
GBM	GRB10 →	-0.767	-0.179	.009	.001	3	3
LSCC	TBL1X →	+0.803	+0.145	<.001	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008210 vs PIGW — GBM

Explore this scatter interactively →