Estrogen metabolic process

Across TCGA cell cohorts, RNA activity of the Estrogen metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PNO1, EIF2B3, and GPN3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Estrogen metabolic process activity versus PNO1 in UPPER_AERODIGESTIVE_TRACT (Pearson r = -0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	PNO1 →	-0.790	-0.308	.003	.001	3	5
LUNG_SCLC	EIF2B3 →	-0.696	-0.165	<.001	.003	3	5
UPPER_AERODIGESTIVE_TRACT	GPN3 →	-0.935	-0.384	.003	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	KARS1 →	-0.811	-0.289	.002	.005	3	4
UPPER_AERODIGESTIVE_TRACT	NUP37 →	-1.178	-0.282	.005	.001	3	4
SKIN	TWF2 →	-0.805	-0.284	.007	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008210 vs PNO1 — UPPER_AERODIGESTIVE_TRACT

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