Androgen metabolic process

Across TCGA patient cohorts, RNA activity of the Androgen metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MZB1, RCN3, and SEC24D, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Androgen metabolic process activity versus MZB1 in BRCA (Pearson r = -0.16).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MZB1 →	-0.725	-0.034	.001	.003	3	6
OV	RCN3 →	+0.467	+0.032	.001	.001	3	5
GBM	SEC24D →	+0.343	+0.068	<.001	<.001	3	5
HNSC	DOCK8_S904 →	-0.516	-0.053	<.001	.001	3	5
GBM	PIKFYVE →	-0.141	-0.064	<.001	.002	3	5
LSCC	PPP1R18 →	-0.266	-0.044	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008209 vs MZB1 — BRCA

Explore this scatter interactively →