Androgen metabolic process

Across TCGA patient cohorts, RNA activity of the Androgen metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SPP1, TREML3P, and MMP9, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Androgen metabolic process activity versus SPP1 in UCEC (Pearson r = 0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SPP1 →	+1.892	+0.505	<.001	.002	3	8
LSCC	TREML3P →	+1.280	+0.648	<.001	<.001	3	8
BRCA	MMP9 →	+1.340	+0.635	.001	<.001	3	7
GBM	SLC11A1 →	+0.836	+0.256	<.001	<.001	3	7
PDAC	ENTHD1 →	+1.235	+0.511	<.001	<.001	3	7
PDAC	GAPDH →	+0.565	+0.374	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008209 vs SPP1 — UCEC

Explore this scatter interactively →