Androgen metabolic process

Across TCGA cell cohorts, RNA activity of the Androgen metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM9, ADAM19, and CCDC136, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TMEM9 grouped by Androgen metabolic process-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	TMEM9 →	-1.546	-1.132	.004	.006	3	5
UPPER_AERODIGESTIVE_TRACT	ADAM19 →	-1.970	-1.271	<.001	.001	3	4
STOMACH	CCDC136 →	-1.914	-1.214	<.001	<.001	3	4
STOMACH	NRSN2 →	-2.375	-1.155	.001	<.001	3	4
STOMACH	PRKCSH →	-0.457	-0.918	<.001	.008	3	4
STOMACH	NCKAP5L →	-1.520	-1.461	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TMEM9 by Androgen metabolic process activity — STOMACH

Explore this box plot interactively →