C21-steroid hormone metabolic process

Across TCGA patient cohorts, RNA activity of the C21-steroid hormone metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are AKR1C2, SCAF4, and SLPI, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, C21-steroid hormone metabolic process activity versus AKR1C2 in LSCC (Pearson r = 0.68).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	AKR1C2 →	+1.442	+0.098	<.001	<.001	3	6
LSCC	SCAF4 →	-0.234	-0.073	.008	.001	3	5
PDAC	SLPI →	+0.810	+0.059	.001	<.001	3	5
HNSC	DHRS9 →	+0.888	+0.077	<.001	<.001	3	5
GBM	DPT →	+0.690	+0.077	<.001	<.001	3	5
CCRCC	GP6 →	+1.093	+0.072	.002	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008207 vs AKR1C2 — LSCC

Explore this scatter interactively →