C21-steroid hormone metabolic process

Across TCGA patient cohorts, RNA activity of the C21-steroid hormone metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DAB2, POLR1C, and FOLR2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, C21-steroid hormone metabolic process activity versus DAB2 in LSCC (Pearson r = 0.06).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	DAB2 →	+0.795	+0.638	<.001	<.001	3	6
LUAD	POLR1C →	-0.317	-0.665	.001	.001	3	5
GBM	FOLR2 →	+0.791	+0.317	.001	.003	3	5
BRCA	CHTF18 →	-0.740	-0.493	<.001	.007	3	4
GBM	EDIL3 →	+1.146	+0.427	.004	.004	3	4
LSCC	ALKBH2 →	-0.445	-0.388	.005	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008207 vs DAB2 — LSCC

Explore this scatter interactively →