C21-steroid hormone metabolic process

Across TCGA patient cohorts, RNA activity of the C21-steroid hormone metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TACC3_S434, CENPC_S73, and MED14, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, C21-steroid hormone metabolic process activity versus TACC3_S434 in UCEC (Pearson r = -0.13).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TACC3_S434 →	-0.806	-0.798	<.001	<.001	3	4
OV	CENPC_S73 →	-1.194	-0.661	<.001	<.001	3	4
BRCA	MED14 →	-0.194	-0.443	<.001	.003	3	4
LSCC	AKR1C3_S129 →	+1.462	+0.555	.001	<.001	3	4
PDAC	FABP4 →	+1.233	+0.211	<.001	<.001	3	3
BRCA	RFC1_S108 →	-0.554	-0.453	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008207 vs TACC3_S434 — UCEC

Explore this scatter interactively →