C21-steroid hormone metabolic process

Across TCGA cell cohorts, RNA activity of the C21-steroid hormone metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EHMT1, THOC6, and CDK16, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, C21-steroid hormone metabolic process activity versus EHMT1 in LARGE_INTESTINE (Pearson r = -0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	EHMT1 →	-0.550	-0.268	<.001	.006	3	4
UPPER_AERODIGESTIVE_TRACT	THOC6 →	-0.727	-0.171	.003	.001	3	4
URINARY_TRACT	CDK16 →	+0.921	+0.223	.003	.004	3	4
SKIN	POPDC2 →	+0.452	+0.259	.003	<.001	3	4
BLOOD_Leukemia	SPRYD3 →	-0.646	-0.196	.003	.003	3	4
OVARY	YPEL2 →	-1.111	-0.194	.002	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008207 vs EHMT1 — LARGE_INTESTINE

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