Negative regulation of DNA replication

Across TCGA cell cohorts, RNA activity of the Negative regulation of DNA replication pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TLN2, IRF7, and CCNH, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TLN2 grouped by Negative regulation of DNA replication-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	TLN2 →	+1.158	+0.265	.001	<.001	3	5
SKIN	IRF7 →	-0.911	-0.178	.002	.003	3	5
URINARY_TRACT	CCNH →	-0.806	-0.224	.005	<.001	2	5
URINARY_TRACT	DPY19L1 →	-0.968	-0.224	.001	<.001	3	4
PANCREAS	FLCN →	-0.973	-0.210	.003	.003	3	4
PANCREAS	GYS1 →	+0.967	+0.193	.002	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TLN2 by Negative regulation of DNA replication activity — KIDNEY

Explore this box plot interactively →