Actin polymerization or depolymerization

Across TCGA patient cohorts, RNA activity of the Actin polymerization or depolymerization pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SERBP1, DCN, and GUCY1A1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Actin polymerization or depolymerization activity versus SERBP1 in OV (Pearson r = -0.46).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SERBP1 →	-0.352	-0.053	<.001	<.001	3	10
BRCA	DCN →	+0.642	+0.016	<.001	<.001	3	10
OV	GUCY1A1 →	+0.501	+0.037	.001	.002	3	10
BRCA	TBC1D2B →	+0.326	+0.022	<.001	<.001	3	10
HNSC	PPM1F →	+0.230	+0.047	<.001	<.001	3	10
OV	PRKG1 →	+0.708	+0.043	<.001	.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008154 vs SERBP1 — OV

Explore this scatter interactively →