Actin polymerization or depolymerization

Across TCGA cell cohorts, RNA activity of the Actin polymerization or depolymerization pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDK9, HMBS, and FNBP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CDK9 grouped by Actin polymerization or depolymerization-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	CDK9 →	-0.378	-0.060	<.001	.001	3	5
BREAST	HMBS →	+0.142	+0.066	.002	.004	3	5
LIVER	FNBP1 →	+0.235	+0.127	<.001	.004	3	5
SOFT_TISSUE	COQ3 →	-0.286	-0.072	.002	.005	3	5
CNS	HOXB8 →	-0.216	-0.076	<.001	<.001	3	5
CNS	RAG2 →	+0.209	+0.064	.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CDK9 by Actin polymerization or depolymerization activity — BLOOD_Myeloma

Explore this box plot interactively →