Actin polymerization or depolymerization

Across TCGA cell cohorts, RNA activity of the Actin polymerization or depolymerization pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LRRFIP1, RALB, and TWF2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Actin polymerization or depolymerization activity versus LRRFIP1 in OVARY (Pearson r = 0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	LRRFIP1 →	+0.736	+0.238	.007	.008	2	7
OVARY	RALB →	+1.171	+0.306	<.001	<.001	3	6
CNS	TWF2 →	+0.581	+0.196	.001	.003	3	6
OESOPHAGUS	SCP2 →	+0.757	+0.244	<.001	.001	3	5
OVARY	CIB1 →	+1.476	+0.366	<.001	.001	3	5
LIVER	ARPC1A →	+0.790	+0.403	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008154 vs LRRFIP1 — OVARY

Explore this scatter interactively →