Anterograde axonal transport

Across TCGA cell cohorts, RNA activity of the Anterograde axonal transport pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZSWIM5, BDH1, and CKMT1B, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Anterograde axonal transport activity versus ZSWIM5 in LUNG_NSCLC_LUAD (Pearson r = -0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	ZSWIM5 →	-1.206	-0.190	<.001	<.001	3	5
LARGE_INTESTINE	BDH1 →	-1.319	-0.900	.001	.001	3	5
LARGE_INTESTINE	CKMT1B →	-2.554	-0.813	.001	.004	1	6
LUNG_NSCLC_LUAD	SERF2 →	-0.611	-0.147	<.001	.004	3	4
BONE	VAPA →	+1.780	+0.320	.001	.006	3	4
CNS	TUBB6 →	+0.913	+0.268	.006	.002	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008089 vs ZSWIM5 — LUNG_NSCLC_LUAD

Explore this scatter interactively →