Axo-dendritic transport

Across TCGA patient cohorts, RNA activity of the Axo-dendritic transport pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are VPS13C_S737, RPL24, and HTATSF1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Axo-dendritic transport activity versus VPS13C_S737 in LSCC (Pearson r = -0.17).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	VPS13C_S737 →	-0.385	-0.029	.006	.001	3	6
GBM	RPL24 →	-0.320	-0.039	.001	<.001	3	5
LUAD	HTATSF1 →	+0.281	+0.028	.001	.004	3	5
LSCC	OPA1 →	+0.415	+0.029	.001	.005	3	5
LSCC	TNKS1BP1_S1073 →	-0.745	-0.041	<.001	<.001	3	5
LSCC	MAP1B_S891 →	+1.256	+0.047	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008088 vs VPS13C_S737 — LSCC

Explore this scatter interactively →