Axo-dendritic transport

Across TCGA cell cohorts, RNA activity of the Axo-dendritic transport pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LY96, RGL1, and FAM160B1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LY96 grouped by Axo-dendritic transport-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	LY96 →	+3.159	+0.177	<.001	.004	3	4
BLOOD_Myeloma	RGL1 →	+3.119	+0.205	<.001	.006	3	4
KIDNEY	FAM160B1 →	+0.786	+0.181	<.001	.001	3	4
OESOPHAGUS	MSI2 →	-0.835	-0.129	.003	.004	3	4
STOMACH	TOR1A →	+0.915	+0.241	.001	.003	3	4
STOMACH	GCHFR →	-2.925	-0.278	<.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LY96 by Axo-dendritic transport activity — BONE

Explore this box plot interactively →