Axo-dendritic transport

Across TCGA cell cohorts, RNA activity of the Axo-dendritic transport pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SEPTIN2, PHIP, and HDAC2, each associated with the pathway in up to 14 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Axo-dendritic transport activity versus SEPTIN2 in BREAST (Pearson r = 0.58).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	SEPTIN2 →	+1.017	+0.064	<.001	<.001	3	13
LUNG_SCLC	PHIP →	+1.153	+0.091	<.001	<.001	3	13
LUNG_NSCLC_LUSC	HDAC2 →	+0.907	+0.078	.004	.003	2	14
LUNG_NSCLC_LUSC	HSF2 →	+1.595	+0.089	.001	.002	2	13
LUNG_NSCLC_LUSC	TLK1 →	+0.991	+0.099	.001	<.001	3	12
BLOOD_Lymphoma	KIF1B →	+1.754	+0.057	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008088 vs SEPTIN2 — BREAST

Explore this scatter interactively →