Axo-dendritic transport

Across TCGA cell cohorts, RNA activity of the Axo-dendritic transport pathway is significantly associated with the protein abundance of multiple proteins, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are UBE2K, ARL8A, and BTF3, each associated with the pathway in up to 13 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Axo-dendritic transport activity versus UBE2K in OESOPHAGUS (Pearson r = -0.56).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	UBE2K →	-1.400	-0.313	<.001	<.001	3	13
LUNG_NSCLC_LUSC	ARL8A →	+1.481	+0.268	<.001	<.001	3	13
LARGE_INTESTINE	BTF3 →	-1.756	-0.326	<.001	<.001	3	13
STOMACH	NUDT5 →	-2.372	-0.344	<.001	<.001	3	13
BONE	RPN1 →	+0.617	+0.179	<.001	<.001	3	12
STOMACH	PPIA →	-2.481	-0.286	.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008088 vs UBE2K — OESOPHAGUS

Explore this scatter interactively →