Mesodermal cell migration

pathway activity — cross-omics
GO:0008078Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Mesodermal cell migration pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CRTAP, TPM4, and CNN2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
BRCACRTAP →-0.590-0.083<.001.00138
LSCCTPM4 →-0.335-0.091<.001<.00138
GBMCNN2 →-0.812-0.112<.001<.00137
OVCOPZ2 →-0.690-0.078.002.00528
PDACFAP →-0.567-0.115<.001<.00137
LUADGPX8 →-0.457-0.085<.001<.00137
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration